TEAM

Andrey Tvardovskiy, Ph.D., Principal Investigator

Andrey is an Assistant Professor in the Department of Biochemistry and Biophysics and a Core Member of the Epigenetics Institute at the University of Pennsylvania. His research program bridges the fields of proteomics, chromatin biology, and aging, with a focus on decoding the intricate epigenetic circuits that govern genome function and the mechanisms underlying their dysregulation during aging.

Andrey earned his Ph.D. in Biochemistry and Molecular Biology from the University of Southern Denmark, where he developed and applied quantitative mass spectrometry techniques to dissect the molecular complexity and functional crosstalk of histone post-translational modifications. His doctoral work pioneered the first comprehensive quantitative analysis of lifelong changes in combinatorial histone modification patterns and histone sequence variants, offering insights into potential mechanisms underlying chromatin reorganization during aging. As a postdoctoral researcher in the Till Bartke Lab at the Helmholtz Center Munich, Andrey focused on investigating how nuclear proteins decode chromatin modification landscapes to orchestrate key genomic processes. His work contributed to the first systematic characterization of how complex modification patterns define and regulate functional chromatin states.

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