Decoding the language of chromatin modifications with MARCS

Tvardovskiy A*, Lukauskas S

* - corresponding author

Nature Reviews Genetics, 2024 (PubMed) (PDF) (MARCS) 

Decoding chromatin states by proteomic profiling of nucleosome readers

Lukauskas S*, Tvardovskiy A*, Nguyen N.V*, Stadler M, Faull P, Ravnsborg T, Aygenli B.Ö, Dornauer S, Flynn H, Lindeboom R.G.H, Barth T.K, Brockers K, Hauck S.M, Vermeulen M, Snijders A.P, Müller C.L, DiMaggio P.A, Jensen O.N, Schneider R, Bartke T.

* - These authors contributed equally

Nature, 2024 (PubMed) (PDF)

Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability

Gaggioli V, Lo C.S.Y, Reveron-Gomez N, Jasencakova Z, Domenech H, Nguyen H, Sidoli S, Tvardovskiy A, Uruci S, Slotman J.A, Chai Y, Goncalves J.G.S.C.S, Manolika E.M, Jensen O.N, Wheeler D, Sridharan S, Chakrabarty S, Demmers J, Kanaar R, Groth A, Taneja N

Nature Cell Biology, 2023 (PubMed) (PDF)

Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control

Weiss M, Chanou A, Schauer T, Tvardovskiy A, Meiser S, Konig A.C, Schmidt T, Kruse E, Ummethum H, Trauner M, Werner M, Lalonde M, Hauck S.M, Scialdone A, Hamperl S.

Cell Reports, 2023 (PubMed) (PDF)

The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program

Wang X.K, Rosikiewicz W, Sedkov Y, Mondal B, Martinez T, Kallappagoudar S, Tvardovskiy A, Bajpai R, Xu B.S, Pruett-Miller S.M, Schneider R, Herz H.M

Life Science Alliance, 2022 (Pubmed) (PDF)

Identifying specific protein interactors of nucleosomes carrying methylated histones using quantitative mass spectrometry

Tvardovskiy A*, Nguyen N*, Bartke T.

* - These authors contributed equally

Methods in Molecular Biology, 2022 (PubMed) 

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation

Stolz P, Mantero A.S, Tvardovskiy A, Ugur E, Wange L.E, Mulholland C.B, Cheng Y.Y, Wierer M, Enard W, Schneider R, Bartke T, Leonhardt H, Elsasser S.J, Bultmann S.

Nucleic Acids Research, 2022 (PubMed) (PDF)

Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis

Michl-Holzinger P, Obermeyer S, Markusch H, Pfab A, Ettner A, Bruckmann A, Babl S, Langst G, Schwartz U, Tvardovskiy A, Jensen O.N, Osakabe A, Berger F, Grasser K.D.

Nucleic Acids Research, 2022 (PubMed) (PDF)

Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A

Maree J.P, Tvardovskiy A, Ravnsborg T, Jensen O.N, Rudenko G, Patterton H.G.

Nucleic Acids Research, 2022 (PubMed) (PDF)

Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin

Skalska L, Begley V, Beltran M, Lukauskas S, Khandelwal G, Faull P, Bhamra A, Tavares M, Wellman R, Tvardovskiy A, Foster B.M, de los Mozos I.R, Herrero J, Surinova S, Snijders A.P, Bartke T, Jenner R.G.

Molecular Cell, 2021 (PubMed)

G-tract RNA removes Polycomb repressive complex 2 from genes

Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster B.M, Worlock K.B, Tvardovskiy A, Kunzelmann S, Herrero J, Bartke T, Gamblin S.J, Wilson J.R, Jenner R.G.

Nature Structural Molecular Biology, 2019 (PubMed)

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

Hojfeldt J.W, Laugesen A, Willumsen B.M, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen O.N, Helin K.

Nature Structural Molecular Biology, 2018 (PubMed)

Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape

Tvardovskiy A, Schwammle V, Kempf S.J, Rogowska-Wrzesinska A, Jensen O.N.

Nucleic Acids Research, 2017 (PubMed) (PDF)

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

Mohammad F, Weissmann S, Leblanc B, Pandey D.P, Hojfeldt J.W, Comet I, Zheng C, Johansen J.V, Rapin N, Porse B.T, Tvardovskiy A, Jensen O.N, Olaciregui N.G, Lavarino C, Sunol M, de Torres C, Mora J, Carcaboso A.M, Helin K.

Nature Medicine, 2017 (PubMed)

Top-down and middle-down protein analysis reveals that intact and clipped human histones differ in post-translational modification patterns

Tvardovskiy A, Wrzesinski K, Sidoli S, Fey S.J, Rogowska-Wrzesinska A, Jensen O.N.

Molecular & Cellular Proteomics, 2015 (PubMed) (PDF)

Serum immunoproteomics combined with pathological reassessment of surgical specimens identifies TCP-1 zeta autoantibody as a potential biomarker in thyroid neoplasia

Belousov P.V, Bogolyubova A.V, Kim Y.S, Abrosimov A.Y, Kopylov A.T, Tvardovskiy A, Lanshchakov K.V, Sazykin A.Y, Dvinskikh N.Y, Bobrovskaya Y.I, Selivanova L.S, Shilov E.S, Schwartz A.M, Shebzukhov Y.V, Severskaia N.V, Vanushko V.E, Moshkovskii S.A, Nedospasov S.A, Kuprash D.V.

The Journal of Clinical Endocrinology & Metabolism, 2015 (PubMed)