CHROMATIN | PROTEOMICS | AGING
Our work bridges chromatin biology and quantitative proteomics to uncover the epigenetic mechanisms that control genome function throughout life
We study how lifelong remodeling of the chromatin modification landscape contributes to aging and disease
We develop mass spectrometry–based quantitative proteomics tools for chromatin research
RESEARCH OVERVIEW
We are interested in understanding how progressive changes in the molecular organization of chromatin over the course of life affect genome function and contribute to aging. By combining cutting-edge mass spectrometry-based proteomics with genomics and biochemical methods, we aim to provide mechanistic insights into longstanding questions:
How do chromatin protein composition and epigenetic modification landscape of mammalian cells change throughout life?
What are the underlying causes of epigenetic changes with age?
How do these changes affect genome stability and transcription, and what role do they play in age-related functional decline and pathologies?
Our overarching goal is to identify the factors that drive deleterious epigenetic aberrations associated with aging and to dissect pathways that can be manipulated to extend a healthy human lifespan.
WE ARE HIRING
We are recruiting motivated and passionate individuals at all levels, including:
Research Specialists
Graduate Students
Any graduate student in CAMB or BBCB is welcome to apply. Students from other graduate groups who are interested in joining the lab are also encouraged to contact us so we can explore possible options. To arrange a rotation, please email us with a brief description of your research interests and your CV.Postdoctoral Fellows.
Are you interested in developing and applying cutting-edge proteomics approaches to address fundamental questions in chromatin and aging biology?
NEWS
August 2026
We are thrilled to announce that the Tvardovskiy Lab is finally open! Due to an 18-month delay in Andrey’s visa approval, the opening date had to be postponed from January 1, 2025, to August 1, 2026. We are deeply grateful for the support we received during this challenging journey.
April 2026
A very warm welcome to our outstanding new Research Associate, Kevin Janssen! We are thrilled to have him join the lab.
March 2026
The Tvardovskiy Lab is getting ready to install the Orbitrap Astral — a state-of-the-art mass spectrometer combining Orbitrap technology with the novel Astral analyzer. We are excited to explore the new technical possibilities it offers for quantitative proteomics in epigenetic research and beyond.
