CHROMATIN | PROTEOMICS | AGING

Our work focuses on developing and applying cutting-edge quantitative proteomics tools to dissect intricate chromatin regulatory circuits and uncover the mechanisms underlying their misregulation during aging.

RESEARCH OVERVIEW

We are interested in understanding how dynamic changes in chromatin organization over the course of life impact genome function and contribute to aging. By combining cutting-edge mass spectrometry-based proteomics with genomics and biochemical methods, we aim to provide mechanistic insights into longstanding questions:

  1. How do chromatin protein composition and epigenetic landscape of mammalian cells change throughout life?

  2. How do these changes affect genome stability and transcription, and what role do they play in age-related functional decline and pathologies?

  3. What are the underlying causes of epigenetic changes with age?

Our overarching goal is to identify the factors that drive deleterious epigenetic aberrations associated with aging and to dissect pathways that can be manipulated to extend a healthy human lifespan. .LEARN.MORE.

WE ARE HIRING

We are recruiting motivated and passionate individuals at all levels, including:

- Research Specialists 
- Graduate Students (3 open positions, next rotation starts in March 2025)
(Only available to students currently enrolled at Penn)
- Postdoctoral Fellows.

Are you excited about the opportunity to learn, apply, and develop cutting-edge proteomics methods and take on ambitious projects to tackle fundamental puzzles in chromatin and aging biology? .JOIN.OUR.TEAM!.

NEWS

07/2024: Two research highlights featuring .MARCS. - the Modification Atlas of Regulation by Chromatin States - are out in Nature Reviews Genetics (link) and Epigenomics (link). We developed MARCS as an interactive web tool to communicate our findings, offering actionable insights into chromatin regulatory circuits. MARCS addresses critical questions, such as which chromatin modifications are recognized by specific nuclear proteins and what the bona fide readers of particular modifications are. Learn more by visiting MARCS (link) and reading our recent research article (link). 

04/2024: Andrey Tvardovskiy is thrilled to announce that he will be joining the University of Pennsylvania as an Assistant Professor in the Department of Biochemistry and Biophysics and a core member of the Epigenetics Institute in January 2025. Stay tuned for updates!